ELTE Computational Virology Lab
Our group is interested in the data analysis, modeling and evolutionary theory of diseases, with an emphasis on viral infections.
Goals & methods
Our theoretical expertise spans virology, immunology, evolutionary biology, bioinformatics, and the modeling of biological systems.
We conduct analyses using bioinformatics algorithms and pipelines, statistical methods, and mathematical and simulation modeling.
Research areas
We model the within-host dynamics of viral infections, with a primary focus on HIV.
We simulate and analyze the spread of epidemics.
We conduct genomic and phylogenetic analyses to uncover patterns in the transmission and evolution of viral pathogens.
We formulate and test evolutionary hypotheses related to health and disease.
Recent publications
- Zsichla, L.; Adravecz, L.; Müller, D.; Lemey, P.; Lakatos, Á.; Ari, E.; Kusejko, K.; Kouyos, R.; Szlávik. J.; Lakatos, B.; Áy, É. and Müller, V. Molecular epidemiology of HIV-1 in Hungary: an evolving contact zone of colliding virus subtypes. Front. Microbiol. 2025, 16:1732254. doi: 10.3389/fmicb.2025.1732254
- Dencs, Á.; Hettmann, A.; Zsichla, L.; Müller, V.; Dömötör, A.; Barna-Lázár, Á.; Barcsay, E.; Takács, M. Molecular Epidemiology of Hepatitis E Virus in Hungary (2018–2025): Emergence of Rare Subtypes and First Detection of HEV-4 in Central Europe. Viruses 2025, 17, 1389, doi:10.3390/v17101389.
- Zsichla, L.; Zeeb, M.; Fazekas, D.; Áy, É.; Müller, D.; Metzner, K.J.; Kouyos, R.D.; Müller, V. Comparative Evaluation of Open-Source Bioinformatics Pipelines for Full-Length Viral Genome Assembly. Viruses 2024, 16, 1824, doi:10.3390/v16121824.
- Zsichla, L.; Müller, V. Risk Factors of Severe COVID-19: A Review of Host, Viral and Environmental Factors. Viruses 2023, 15, 175, doi:10.3390/v15010175.
- Sousa, J.D.; Müller, V.; Vandamme, A.-M. The Impact of Genital Ulcers on HIV Transmission Has Been Underestimated—A Critical Review. Viruses 2022, 14, 538, doi:10.3390/v14030538.
Team members
Viktor Müller, PhD
Viktor Müller is PI of the National Laboratory for Health Security at Eötvös Loránd University, Budapest. He is also Vice Dean at the Faculty of Science.
Éva Áy, PhD
(part-time)
Éva Áy is a molecular biologist at the National Center for Public Health and Pharmacy, Budapest, Hungary and a research associate at the National Laboratory for Health Security, at Eötvös Loránd University, Budapest, Hungary. She currently leads the National Reference Laboratory for Retroviruses.
Levente Zsichla, MSc
Levente Zsichla received his Master’s degree in Biology with a specialization in Bioinformatics, and is a research assistant at the National Laboratory for Health Security, at Eötvös Loránd University, Budapest, Hungary.
Anu Bazarragchaa, MSc
Anu Bazarragchaa is a Research Assistant at Eötvös Loránd University. She holds an MSc. in Biology from Eötvös Loránd University and a BSc. in Biological Sciences from the University of Debrecen.
Dóra Sipos, MSc
(part-time)
Dóra Sipos received her master’s degree in Biology at the Faculty of Veterinary Sciences. She’s research assistant at HUN-REN Veterinary Medical Research Institute and at Eötvös Loránd University.
Lilla Adravecz, MSc
(part-time)
Lilla Adravecz is a biotechnologist at the National Center for Public Health and Pharmacy, Budapest, Hungary and a research associate at the National Laboratory for Health Security, at Eötvös Loránd University, Budapest, Hungary. She received her MSc degree in Medical Biotechnology with a specialization in Applied Bioinformatics from Pázmány Péter Catholic University.
Zoltán Török, BSc
Török Zoltán is a Research Assistant at Eötvös Loránd University. He holds a BSc in biology, currently doing his MSc specialized in bioinformatics.
Past members
- Apari, Péter (publications)
- Bartha, István (publications)
- Ferdinandy, Bence (publications)
- Könnyű, Balázs (publications)
- Mokos, Judit (publications)
- Móréh, Ágnes (publications)
- Müller, Dalma (publications)
Collaborations
NNGYK
We collaborate with the National Center for Public Health and Pharmacy on analyses of the molecular epidemiology of HIV in Hungary.
DPCK
We work with the South-Pest Hospital Centre on analyses of the epidemiology of HIV in Hungary.
ENL
We are part of the National Laboratory for Health Security in Hungary.
SHCS
We collaborate with the SHCS and the University Hospital of Zurich on analyses of clinical and genomic HIV data.
KUL
We collaborate with KU Leuven towards a better understanding of the origin of the HIV pandemic.
CONTACT
Our Address
Pázmány Péter sétány 1/C., Budapest, H-1117, Hungary
Room 7.503
Call us
Phone/ext.: +36-1-3722500/8798
Email us
mueller.viktor@ttk.elte.hu